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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36296 | BIO5192 hydrate | ||
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05762 |
Integrin alpha X beta 2 Protein, Human, Recombinant (His)
Integrin α X β 2,integrin, al... |
Human | HEK293 Cells |
Integrin alpha X beta 2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 204.8 kDa and the accession number is P20702&P05107. | |||
TMPY-02161 |
Integrin alpha X beta 2 Protein, Human, Recombinant (Flag & His)
integrin, α X (complement component 3 rece... |
Human | HEK293 Cells |
Integrin alpha X beta 2 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 205 kDa and the accession number is P20702&P05107. | |||
TMPJ-00952 |
CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-... |
Mouse | E. coli |
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... |